Download PDF by M. Benkö, B. Harrach (auth.), Prof.Dr. Walter Doerfler,: Adenoviruses: Model and Vectors in Virus-Host Interactions:

By M. Benkö, B. Harrach (auth.), Prof.Dr. Walter Doerfler, Petra Böhm (eds.)

ISBN-10: 3642055176

ISBN-13: 9783642055171

ISBN-10: 366205597X

ISBN-13: 9783662055977

After 3 volumes on adenoviruses in 1995 the prior years have noticeable swift development within the box of adenovirus examine. furthermore, adenoviruses have attracted substantial curiosity as vectors in gene move regimens.

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Extra info for Adenoviruses: Model and Vectors in Virus-Host Interactions: Virion-Structure, Viral Replication and Host-Cell Interactions

Example text

The dsDNA genome of phage PRD 1 is almost 15 kb. It has ITRs, and contains the genes of two important proteins (terminal protein and DNA polymerase) in the same order as they are in adenoviruses (BAMFORD and ACKERMANN 2000). The terminal protein of phage PRDI also acts as protein primer in viral DNA replication, a rare feature that occurs, besides in adenoviruses, only in cJ>29 phage (SALAS 1983). A recent study on the resolution of the hexon (P3) protein structure of phage PRD 1 revealed an arrangement very similar to that found in the hexon of HAdV-2 (BURNETT 1997) suggesting an evolutionary link between adenoviruses and tectiviruses (BENSON et al.

The mastadenoviral genome should be considered as being the most highly organized and most efficient protein synthesis system, which also has acquired sophisticated regulatory mechanisms for optimal interaction with the host cells and with the immune system of the animal. Our opinion opposes the hypothesis of ROSA-CALATRAVA et al. (2001) who speculate, that "viruses, as obligatory cell parasites, usually evolved toward the highest possible degree of simplification of their structure and components ...

Gene 55:85-93 SONG B, Hu S-L, DARAI G, SPINDLER KR, YOUNG CSH (1996) Conservation of DNA sequence in the predicted major late promoter regions of selected Mastadenoviruses. Virology 220:390-401 THOMSON D, MEERS J, HARRACH B (2002) Molecular confirmation of an adenovirus in brushtail possums (Trichosurus vulpecula). Virus Res 83:189-195 URSU K, ZADORI Z, BENKO M, MATIZ K, DAN A, HARRACH B (1997) Mapping of naturally occurring deletions in bovine adenovirus isolates. Acta Microbiol Immunol Hung 44:33 VRATI S, BOYLE D, KOCHERHANS R, BOTH GW (1995) Sequence of ovine adenovirus: homologs for lOOK hexon assembly, 33K, pVIII, and fiber genes: early region E3 is not in the expected location.

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Adenoviruses: Model and Vectors in Virus-Host Interactions: Virion-Structure, Viral Replication and Host-Cell Interactions by M. Benkö, B. Harrach (auth.), Prof.Dr. Walter Doerfler, Petra Böhm (eds.)


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