By Derek Kinchington, Raymond F. Schinazi
Skilled scientists describe-in an easily-followed format-their state of the art ideas for comparing antiviral compounds. The assays defined contain platforms for investigating medications used opposed to herpesviruses, hepatitis viruses, human immunodeficiency viruses, human papillomaviruses, and influenza viruses. those well-tested equipment variety from mobile assays to a couple of the main updated molecular ways for picking compounds which are energetic opposed to viral enzymes and the advance of viral resistance opposed to medicines presently in use. well timed and entire, Antiviral equipment and Protocols bargains modern-day researchers in academia, medical departments, and the pharmaceutical the strong, reproducible, and novel tools had to evaluation compounds powerful opposed to either acute and protracted infections.
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Additional info for Antiviral Methods and Protocols (Methods in Molecular Medicine)
9/25061 subject : Antiviral agents--Laboratory manuals, Hepatitis, Viral, Human--drug therapy, Antiviral Agents--therapeutic use, DNA Virus Infections--drug therapy, RNA Virus Infections--drug therapy. Page i Antiviral Methods and Protocols Page ii METHODS IN MOLECULAR MEDICINE John M. Walker, SERIES EDITOR 42. Vaccine Adjuvants: Preparation Methods and Research Protocols, edited by Derek T. O'Hagan, 2000 41. Celiac Disease: Methods and Protocols, edited by Michael N. Marsh, 2000 40. Diagnostic and Therapeutic Antibodies, edited by Andrew J.
Boehme, R. , and Borthwick, A. , and Wyatt, P. G. (1995) Antiviral agents. Ann. Rep. Med. Chem. 30, 144. 16. Ridky, T. and Leis, J. (1995) Development of drug resistance to HIV-1 protease inhibitors. J. Biol. Chem. 270, 29,62129,623. 17. , et al. (1993) Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature 363, 418423. 18. Andries, K. (1993) Discovery of piroclavir, a broad spectrum inhibitor of ethnoviruses, in The Search for Antiviral Drugs, Birkhauser, Germany, pp.
Although these molecules are structurally very different, they bind in a similar region to nevirapine (12). 5 HIV Proteinase Inhibitors The discovery in the mid-1980s that HIV encoded a unique aspartyl proteinase responsible for posttranslational cleavage of the viral polyprotein led to a number of drug research programs in search of inhibitors. These programs represent a paradigm for modern drug discoverywith substrate-based, biostructure-based, and high-throughput screening approaches all successfully employed.
Antiviral Methods and Protocols (Methods in Molecular Medicine) by Derek Kinchington, Raymond F. Schinazi